A take on why lab mice are little use for investigating human illnesses:
Just think about what it would mean if a human experiment were comparable to a mouse experiment. We would be using a population of nothing but 42-year-old white males that live in identical ranch homes in some small town somewhere with identical diets, identical wives, identical children, identical furniture; they eat the same thing every day for every meal, the thermostat is locked, and the gardener is an extremely scary-looking Tyrannosaurus rex that pulls the roof off their house once a week and destroys their Facebook account and all of their social information.
These are Stepford mice! It’s the only field of biology or psychology where we don’t recognise that variation is what makes us special, what makes us interesting – and what makes us ill.
It’s little use manipulating animals, by genetic engineering or otherwise, so that they simulate the symptoms of conditions they don’t really have.
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